Integrating Hallucination Detection Mechanisms in AI-Driven Diagnostic Systems

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Navid Norouzi
Shirin Maleki
Setareh Hosseini

Abstract

The integration of artificial intelligence (AI) in diagnostic systems has revolutionized medical practice by enhancing accuracy and efficiency. However, one of the significant challenges that undermine the reliability of these systems is the phenomenon of AI hallucinations—instances where the AI generates incorrect or misleading information with high confidence. This paper investigates the incorporation of hallucination detection mechanisms within AI-driven diagnostic frameworks, aiming to bolster their trustworthiness and safety.


 


We propose a comprehensive framework that combines state-of-the-art machine learning techniques with robust statistical methods to identify and mitigate hallucinations in real-time. By leveraging anomaly detection algorithms and uncertainty quantification, our approach ensures that the AI system can flag potentially erroneous outputs before they reach the clinician, thus preserving the integrity of the diagnostic process. This framework is designed to be adaptable across various diagnostic domains, ensuring broad applicability and scalability.


 


Our experimental results, conducted on a diverse set of diagnostic tasks, demonstrate a significant reduction in hallucination rates while maintaining high diagnostic accuracy. The proposed mechanisms enhance the AI's ability to self-assess and provide confidence scores that are inversely correlated with hallucination likelihood, thereby enabling practitioners to make more informed decisions. Furthermore, the integration of these mechanisms does not compromise the computational efficiency of the diagnostic systems, making it feasible for real-world deployment.


 


This research contributes to the growing field of AI safety and reliability in healthcare, addressing critical ethical and practical concerns. By systematically reducing the occurrence of hallucinations, we lay the groundwork for more dependable AI diagnostic tools that can be trusted by healthcare professionals and patients alike, ultimately fostering greater acceptance and utilization of AI in clinical settings.

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Integrating Hallucination Detection Mechanisms in AI-Driven Diagnostic Systems. (2026). International Journal of Computational Health & Machine Learning, 4(1). https://ijchml.com/index.php/ijchml/article/view/228

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